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Issue No. 47 | November 1, 2012

News and Features

Updated HHS Pediatric Antiretroviral Treatment Guidelines Now Available

AIDSinfo announces the release of the updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Key updates and new information included in the guidelines are prefaced in What’s New in the Pediatric Guidelines? Additions and revisions are also highlighted in yellow throughout the text and tables of the guidelines.

Selected key updates to the guidelines include:

  • New sections on diagnostic testing in children.
  • Updated recommendations in the When to Start Antiretroviral Therapy section, including guidance on use of CD4 percentage and CD4 count in deciding when to initiate treatment and narrower breakdown of age groups for CD4 thresholds for initiating therapy.
  • Updates to What Drugs to Start, including Panel recommendations regarding several ARVs with recent FDA-approved indications in children.
  • Added information regarding pregnancy outcomes in adolescent girls, as well as updates concerning interactions between ARVs and contraceptives.
  • Consideration of newer individual ARVs and classes of ARVs in discussion of Management of Treatment-Experienced Infants, Children, and Adolescents and revisions to Table 20 of new regimen options for children with treatment failure.
  • The addition of new pediatric data for specific drugs in the Pediatric Antiretroviral Drug Information Appendix.

For a complete preview of key updates to the guidelines, see What’s New in the Pediatric Guidelines?

To view or download the guidelines, go to the Pediatric Guidelines section of AIDSinfo. Separate PDF files of the tables or recommendations can also be downloaded from the page.

Your Feedback Is Welcome

The HHS Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children invites feedback on the latest revisions to the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Please send your comments with the subject line "Comments on Pediatric Guidelines" to by November 14, 2012.