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Issue No. 33 | August 3, 2012

News and Features

NIH-Funded Treatment-as-Prevention Study (HPTN 052) Demonstrates Additional Health Benefits and Cost-Effectiveness

“Further analyses of the landmark NIH-funded treatment-as-prevention study (HPTN 052) have found that providing antiretroviral treatment to HIV-infected individuals earlier, when their immune systems are healthier, delays AIDS-related health events, such as chronic herpes simplex virus and tuberculosis, as well as death. Additionally, researchers found that earlier HIV treatment is also cost-effective because it increases survival, prevents costly opportunistic infections and averts transmission of the virus to uninfected individuals.

“The two analyses were presented at the XIX International AIDS Conference (AIDS 2012) in Washington, D.C. …

“Initial results from the HPTN 052 study, announced in 2011, demonstrated that earlier use of antiretrovirals by HIV-infected heterosexuals partnered with uninfected individuals (serodiscordant couples) reduced HIV transmission by 96 percent. In two years of follow-up analysis of 1,761 HIV-infected study participants, researchers compared those who delayed antiretroviral treatment until their CD4+ T-cell counts were an average of 230 cells/ per cubic millimeter (mm³) with those who began antiretroviral treatment sooner (an average CD4 level of 440 cells/ mm³). The delayed group experienced a shorter time to a primary clinical event, including AIDS-defining disease and all types of tuberculosis. … The trial provides evidence that earlier antiretroviral treatment among the HIV-infected provides significant health benefits.”

More information is available:

CDC Releases New and Updated HIV/AIDS Fact Sheets

Additions to CDC’s collection of HIV/AIDS fact sheets include:

  • New fact sheet: “HIV in Correctional Settings.” The fact sheet provides information on the prevalence of HIV and AIDS among state and federal prisoners and challenges to implementing HIV testing, treatment, and prevention programs in correctional settings. In addition, the fact sheet outlines CDC support for related HIV prevention interventions. 
  • Updated fact sheet: “HIV and AIDS in the United States by Geographic Distribution.” The fact sheet provides information and statistics on the HIV and AIDS epidemic in the United States, including breakdowns by state, region, and race/ethnicity. The fact sheet also provides examples of how CDC invests its HIV prevention resources in the places and populations most affected by HIV infection.