Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Appendix B: Drug Characteristics Tables

Coformulated Single-Tablet Regimens

Last Updated: July 10, 2019; Last Reviewed: July 10, 2019

Appendix B, Table 1. Coformulated Single-Tablet Regimens

The following table includes dose recommendations for FDA-approved STR products. Please see the class-specific drug characteristics tables (Appendix B, Tables 3 to 6) for details about the individual drugs contained in these STR products, including information on elimination and metabolic pathways, serum and intracellular half-lives, and adverse effects. Drugs listed in this table are arranged in alphabetical order by trade name within each section.

Appendix B, Table 1. Coformulated Single-Tablet Regimens
Trade Name
(Abbreviations)
ARV Drugs Included in the STR Dosing Recommendationa
INSTI plus Two NRTIs
Biktarvy
(BIC/TAF/FTC)
Bictegravir 50 mg/tenofovir alafenamide 25 mg/emtricitabine 200 mg One tablet once daily
Genvoya
(EVG/c/TAF/FTC)
Elvitegravir 150 mg/cobicistat 150 mg/tenofovir alafenamide 10 mg/emtricitabine 200 mg One tablet once daily with food
Stribild
(EVG/c/TDF/FTC)
Elvitegravir 150 mg/cobicistat 150 mg/tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg One tablet once daily with food
Triumeq
(DTG/ABC/3TC)
Dolutegravir 50 mg/abacavir 600 mg/lamivudine 300 mg One tablet once daily
INSTI plus One NRTI
Dovato
(DTG/3TC)
Dolutegravir 50 mg/lamivudine 300 mg One tablet once daily
PI plus Two NRTIs
Symtuza
(DRV/c/TAF/FTC)
Darunavir 800 mg/cobicistat 150 mg/tenofovir alafenamide 10 mg/emtricitabine 200 mg One tablet once daily with food
NNRTI plus Two NRTIs
Atripla
(EFV/TDF/FTC)
Efavirenz 600 mg/tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg One tablet once daily on an empty stomach, preferably at bedtime
Complera
(RPV/TDF/FTC)
Rilpivirine 25 mg/tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg One tablet once daily with a meal
Delstrigo
(DOR/TDF/3TC)
Doravirine 100 mg/tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg One tablet once daily
Odefsey
(RPV/TAF/FTC)
Rilpivirine 25 mg/tenofovir alafenamide 25 mg/emtricitabine 200 mg One tablet once daily with a meal
Symfi
(EFV/TDF/3TC)
Efavirenz 600 mg/tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg One tablet once daily on an empty stomach, preferably at bedtime
Symfi Lo
(EFV/TDF/3TC)
Efavirenz 400 mg/tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg One tablet once daily on an empty stomach, preferably at bedtime
INSTI plus One NNRTI
Juluca
(DTG/RPV)
Dolutegravir 50 mg/rilpivirine 25 mg One tablet once daily with a meal
a For dose adjustments in patients with renal or hepatic insufficiency, see Appendix B, Table 10. When no food restriction is listed, the STR can be taken with or without food.

Key: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; BIC = bictegravir; c = cobicistat; DOR = doravirine; DRV = darunavir; DTG = dolutegravir; EFV = efavirenz; EVG = elvitegravir; FDA = Food and Drug Administration; FTC = emtricitabine; INSTI = integrase strand transfer inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor; NRTI = nucleoside reverse transcriptase inhibitor; PI = protease inhibitor; RPV = rilpivirine; STR = single-tablet regimen; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate

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