Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Appendix B: Drug Characteristics Tables

Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen

Last Updated: July 10, 2019; Last Reviewed: July 10, 2019

Appendix B, Table 2. Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen

The following table includes dose recommendations for FDA-approved, dual-NRTI FDC products. These FDC tablets are not complete regimens and must be administered in combination with other ARV drugs.

Please see the class-specific drug characteristics tables (Appendix B, Tables 3 to 6) for details about the individual drugs contained in these FDC products, including information on elimination and metabolic pathways, serum and intracellular half-lives, and adverse effects. Drugs listed in this table are arranged in alphabetical order by trade names within each section.

Appendix B, Table 2. Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
Trade Name
(Abbreviations)
ARV Drugs Included in the FDC Tablet Dosing Recommendationa
TAF or TDF plus an NRTI
Descovy
(TAF/FTC)
Tenofovir alafenamide 25 mg/emtricitabine 200 mg One tablet once daily
Cimduo
(TDF/3TC)
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg One tablet once daily
Temixys
(TDF/3TC)
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg One tablet once daily
Truvada
(TDF/FTC)
Tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg One tablet once daily
Other NRTI-Based FDC Tablets
Epzicom
(ABC/3TC)

Note: Generic is available.
Abacavir 600 mg/lamivudine 300 mg One tablet once daily
Combivir
(ZDV/3TC)

Note: Generic is available.
Zidovudine 300 mg/lamivudine 150 mg One tablet twice daily
a For dose adjustments in patients with renal or hepatic insufficiency, see Appendix B, Table 10. All FDC tablets listed in this table can be taken without regard to food.

Key: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; FDA = Food and Drug Administration; FDC = fixed-dose combination; FTC = emtricitabine; NRTI = nucleoside reverse transcriptase inhibitor; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine

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