Hepatitis B Virus/HIV Coinfection
Last Updated: December 24, 2019; Last Reviewed: December 24, 2019
Panel's Recommendations Regarding Hepatitis B Virus/HIV Coinfection
- All pregnant women living with HIV should be screened during the current pregnancy for:
- Hepatitis B virus (HBV) infection, unless they are already known to have HBV/HIV coinfection or have serologic documentation of HBV immunity, and
- Hepatitis C virus (HCV) infection, unless they are already known to have HCV/HIV coinfection (see Hepatitis C Virus/HIV Coinfection) (AIII).
- All pregnant women with HIV who screen negative for HBV infection (i.e., HBV surface antigen negative, HBV core antibody negative, and HBV surface antibody negative) or who lack HBV immunity (i.e., HBV surface antibody negative) should receive the HBV vaccine series (AII).
- Women with chronic HBV infection who have not already received the hepatitis A virus (HAV) vaccine series should be screened for immunity to HAV. If they screen negative for HAV immunoglobulin G antibody, they should receive the HAV vaccine series (AIII).
- All pregnant and postpartum women with HBV/HIV coinfection should receive antiretroviral therapy (ART) that includes tenofovir disoproxil fumarate (TDF) plus lamivudine or emtricitabine (AI). If a woman with HBV/HIV coinfection becomes pregnant while virally suppressed on an antiretroviral regimen that includes tenofovir alafenamide (TAF), she can be offered the choice of continuing TAF or switching from TAF to TDF (BIII).
- Pregnant women with HBV/HIV coinfection who are receiving ART should be counseled about signs and symptoms of liver toxicity, and liver transaminases should be assessed 1 month after initiating ART and at least every 3 months thereafter during pregnancy (BIII).
- During and after pregnancy, women with chronic HBV should be counseled on the importance of continuing anti-HBV medications indefinitely. If ART that includes medications with anti-HBV activity is discontinued in women with HBV/HIV coinfection, frequent monitoring of liver function tests for potential exacerbation of HBV infection is recommended, with prompt re-initiation of treatment for HBV when a flare is suspected (BIII).
- Decisions concerning mode of delivery of the infant in a pregnant woman with HBV/HIV coinfection should be based on standard obstetric and HIV-related indications alone; HBV/HIV coinfection does not necessitate a cesarean delivery if not otherwise indicated (see Transmission and Mode of Delivery) (AIII).
- Within 12 hours of birth, infants born to women with HBV should receive hepatitis B immune globulin and the first dose of the HBV vaccine series (AI).