Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Archived Drugs

Didanosine (Videx, ddI)

Last Updated: December 7, 2018; Last Reviewed: December 7, 2018

Excerpt from Table 8

Excerpt from Table 8
Generic Name
Trade Name
Formulation Dosing Recommendationsa Use in Pregnancy
Videx EC

ddI (Videx)
Buffered Tablets (Non-EC):
  • No longer available
  • 10 mg/mL oral solution

Videx EC (EC Beadlets) Capsules:
  • 125 mg
  • 200 mg
  • 250 mg
  • 400 mg

Generic Delayed-Release Capsules:
  • 200 mg
  • 250 mg
  • 400 mg
Standard Adult Doses
Body Weight ≥60 kg:
  • ddI 400 mg once daily
With TDF:
  • ddI 250 mg once daily; take 1/2 hour before or 2 hours after a meal.
Body Weight <60 kg:
  • ddI 250 mg once daily
With TDF:
  • ddI 200 mg once daily; take 1/2 hour before or 2 hours after a meal.
Note: Preferred dosing with oral solution is twice daily (total daily dose divided into 2 doses). Take 1/2 hour before or 2 hours after a meal.

Dosing in Pregnancy:
  • No change in dose indicated.
PK in Pregnancy:
  • PK is not significantly altered in pregnancy.
ddI is not recommended for pregnant women.

Low-moderate placental transfer to fetus.b

ddI should not be used with d4T. Lactic acidosis, sometimes fatal, has been reported in pregnant women receiving ddI and d4T together.
a Individual ARV drug dosages may need to be adjusted in patients with renal or hepatic insufficiency (for details, see the Adult and Adolescent Guidelines Appendix B, Table 8).
b Placental transfer categories are determined by mean or median cord blood/maternal delivery plasma drug ratio:
          High: >0.6
          Moderate: 0.3–0.6
          Low: <0.3

Key to Acronyms: ARV = antiretroviral; d4T = stavudine; ddI = didanosine; EC = enteric coated; FDC = fixed-dose combination; PK = pharmacokinetic; TDF = tenofovir disoproxil fumarate

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