Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Nucleoside and Nucleotide Analogue Reverse Transcriptase Inhibitors

Emtricitabine (Emtriva, FTC)

Last Updated: December 7, 2018; Last Reviewed: December 7, 2018

Excerpt from Table 10a

Note: When using FDCs, refer to other sections in Appendix B and Table 10 for information about the dosing and safety of individual drug components of the FDC during pregnancy.

Generic Name
(Abbreviation)
Trade Name
Formulation Dosing Recommendations Use in Pregnancy
Emtricitabine
(FTC)
Emtriva

(FTC/TDF)
Truvada

(FTC/EFV/TDF)
Atripla

(FTC/RPV/TDF)
Complera

(FTC/EVG/COBI/TDF)
Stribild

(FTC/TAF)
Descovy

(FTC/RPV/TAF)
Odefsey

(FTC/EVG/COBITAF)
Genvoya

(FTC/BIC/TAF)
Biktarvy

(FTC/DRV/COBI/TAF)
Symtuza
FTC (Emtriva)
Capsule:
  • 200 mg
Oral Solution:
  • 10 mg/mL


FTC/TDF (Truvada):
  • FTC 200 mg plus TDF 300 mg tablet
FTC/EFV/TDF (Atripla):
  • FTC 200 mg plus TDF 300 mg plus EFV 600 mg tablet
FTC/RPV/TDF (Complera):
  • FTC 200 mg plus TDF 300 mg plus RPV 25 mg tablet
FTC/EVG/COBI/TDF (Stribild):
  • FTC 200 mg plus TDF 300 mg plus EVG 150 mg plus COBI 150 mg tablet
FTC/TAF (Descovy):
  • FTC 200 mg plus TAF 25 mg tablet
FTC/RPV/TAF (Odefsey):
  • FTC 200 mg plus TAF 25 mg plus RPV 25 mg tablet
FTC/EVG/COBI/TAF (Genvoya):
  • FTC 200 mg plus TAF 10 mg plus EVG 150 mg plus COBI 150 mg tablet
FTC/BIC/TAF (Biktarvy):
  • FTC 200 mg plus TAF 25 mg plus BIC 50 mg tablet
FTC/DRV/COBI/TAF (Symtuza):
  • DRV 800 mg plus COBI 150 mg plus FTC 200 mg plus TAF 10 mg tablet
Standard Adult Doses
FTC (Emtriva)
Capsule
:
  • 200 mg once daily without regard to food
Oral Solution:
  • 240 mg (24 mL) once daily without regard to food


FTC/TDF (Truvada):
  • 1 tablet once daily without regard to food
FTC/TDF/EFV (Atripla):
  • 1 tablet once daily at or before bedtime. Take on an empty stomach to reduce side effects.
FTC/TDF/RPV (Complera):
  • 1 tablet once daily with food
FTC/TDF/EVG/COBI (Stribild):
  • 1 tablet once daily with food
FTC/TAF (Descovy):
  • 1 tablet once daily with or without food
FTC/TAF/RPV (Odefsey):
  • 1 tablet once daily with food
FTC/TAF/EVG/COBI (Genvoya):
  • 1 tablet once daily with food
FTC/TAF/BIC (Biktarvy):
  • 1 tablet once daily with or without food
DRV/COBI/FTC/TAF (Symtuza):
  • 1 tablet once daily with food
Dosing in Pregnancy:
  • No change in FTC dose indicated.
PK in Pregnancy:
  • PK of FTC is not significantly altered in pregnancy.
  • For guidance about use of combination products in pregnancy, please see the specific sections on other components (i.e., TDF, TAF, EFV, RPV, DRV, EVG, BIC, COBI)
High placental transfer to fetus.b

No evidence of human teratogenicity (can rule out 1.5-fold increase in overall birth defects).

If patient is HBV-coinfected, it is possible that a HBV flare may occur if the drug is stopped; see HIV/Hepatitis B Virus Coinfection.
a Individual ARV drug dosages may need to be adjusted in patients with renal or hepatic insufficiency (for details, see the Adult and Adolescent Guidelines Appendix B, Table 8).
b Placental transfer categories are determined by mean or median cord blood/maternal delivery plasma drug ratio:
          High: >0.6
          Moderate: 0.3–0.6
          Low: <0.3

Key to Acronyms: BIC = bictegravir; COBI = cobicistat; DRV = darunavir; EFV = efavirenz; EVG = elvitegravir; FDC = fixed-dose combination; FTC = emtricitabine; HBV = hepatitis B virus; PK = pharmacokinetic; RPV = rilpivirine; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate

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