Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Nucleoside and Nucleotide Analogue Reverse Transcriptase Inhibitors

Emtricitabine (Emtriva, FTC)

Last Updated: December 24, 2019; Last Reviewed: December 24, 2019

Excerpt from Table 8

Note: When using FDC tablets, refer to other sections in Appendix B and Table 8 for information about the dosing and safety of individual drug components of the FDC tablet during pregnancy.

Excerpt from Table 8
Generic Name
Trade Name
Formulation Dosing Recommendationsa Use in Pregnancy










Note: Generic products are available for some formulations.
FTC (Emtriva)
  • 200 mg
Oral Solution:
  • 10 mg/mL
FTC/EFV/TDF (Atripla):d
  • FTC 200 mg/EFV 600 mg/TDF 300 mg tablet
FTC/BIC/TAF (Biktarvy):
  • FTC 200 mg/BIC 50 mg/TAF 25 mg tablet
FTC/RPV/TDF (Complera):
  • FTC 200 mg/RPV 25 mg/TDF 300 mg tablet
FTC/TAF (Descovy):
  • FTC 200 mg/TAF 25 mg tablet
FTC/EVG/c/TAF (Genvoya):
  • FTC 200 mg/EVG 150 mg/COBI 150 mg/TAF 10 mg tablet
FTC/RPV/TAF (Odefsey):
  • FTC 200 mg/RPV 25 mg/TAF 25 mg tablet
FTC/EVG/c/TDF (Stribild):
  • FTC 200 mg/EVG 150 mg/COBI 150 mg/TDF 300 mg tablet
FTC/DRV/c/TAF (Symtuza):
  • FTC 200 mg/DRV 800 mg/COBI 150 mg/TAF 10 mg tablet
FTC/TDF (Truvada):d
  • FTC 200 mg/TDF 300 mg tablet
Standard Adult Doses
FTC (Emtriva)
  • FTC 200 mg once daily without regard to food
Oral Solution:
  • FTC 240 mg (24 mL) once daily without regard to food
FTC/EFV/TDF (Atripla):
  • One tablet once daily at or before bedtime
  • Take on an empty stomach to reduce or mitigate side effects.
FTC/BIC/TAF (Biktarvy):
  • One tablet once daily with or without food
FTC/RPV/TDF (Complera):
  • One tablet once daily with food
FTC/TAF (Descovy):
  • One tablet once daily with or without food
FTC/EVG/c/TAF (Genvoya):
  • One tablet once daily with food
FTC/RPV/TAF (Odefsey):
  • One tablet once daily with food
FTC/EVG/c/TDF (Stribild):
  • One tablet once daily with food
FTC/DRV/c/TAF (Symtuza):
  • One tablet once daily with food
FTC/TDF (Truvada):
  • One tablet once daily without regard to food
PKs in Pregnancy:
  • PKs of FTC are not significantly altered in pregnancy.
Dosing in Pregnancy:
  • No change in dose indicated.
For guidance about the use of combination products in pregnancy, please see the specific sections on other components (i.e., TDF, TAF, EFV, RPV, DRV, EVG, BIC, COBI).
High placental transfer to fetus.b

No evidence of human teratogenicity (can rule out 1.5-fold increase in overall birth defects).

If patient has HBV/HIV coinfection, it is possible that a HBV flare may occur if the drug is stopped; see Hepatitis B Virus/HIV Coinfection.
a Individual ARV drug doses may need to be adjusted in patients with renal or hepatic insufficiency (for details, see the Adult and Adolescent Antiretroviral Guidelines, Appendix B, Table 10).
b Placental transfer categories are determined by mean or median cord blood/maternal delivery plasma drug ratio:
          High: >0.6
          Moderate: 0.3–0.6
          Low: <0.3
d Generic product is available.

Key: BIC = bictegravir; COBI = cobicistat; DRV/c = darunavir/cobicistat; EFV = efavirenz; EVG/c = elvitegravir/cobicistat; FDC = fixed-dose combination; FTC = emtricitabine; HBV = hepatitis B virus; PK = pharmacokinetic; RPV = rilpivirine; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate

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