Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV
The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.
Appendix B: Drug Characteristics Tables
Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
Last Updated: July 10, 2019; Last Reviewed: July 10, 2019
Appendix B, Table 2. Nucleoside Reverse Transcriptase Inhibitor-Based, Fixed-Dose Combination Tablets for Use as Part of an Antiretroviral Regimen
The following table includes dose recommendations for FDA-approved, dual-NRTI FDC products. These FDC tablets are not complete regimens and must be administered in combination with other ARV drugs.
Please see the class-specific drug characteristics tables (Appendix B, Tables 3 to 6) for details about the individual drugs contained in these FDC products, including information on elimination and metabolic pathways, serum and intracellular half-lives, and adverse effects. Drugs listed in this table are arranged in alphabetical order by trade names within each section.
Trade Name (Abbreviations) |
ARV Drugs Included in the FDC Tablet | Dosing Recommendationa |
---|---|---|
TAF or TDF plus an NRTI |
||
Descovy (TAF/FTC) |
Tenofovir alafenamide 25 mg/emtricitabine 200 mg | One tablet once daily |
Cimduo (TDF/3TC) |
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg | One tablet once daily |
Temixys (TDF/3TC) |
Tenofovir disoproxil fumarate 300 mg/lamivudine 300 mg | One tablet once daily |
Truvada (TDF/FTC) |
Tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg | One tablet once daily |
Other NRTI-Based FDC Tablets | ||
Epzicom (ABC/3TC) Note: Generic is available. |
Abacavir 600 mg/lamivudine 300 mg | One tablet once daily |
Combivir (ZDV/3TC) Note: Generic is available. |
Zidovudine 300 mg/lamivudine 150 mg | One tablet twice daily |
a For dose adjustments in patients with renal or hepatic insufficiency, see Appendix B, Table 10. All FDC tablets listed in this table can be taken without regard to food.
Key: 3TC = lamivudine; ABC = abacavir; ARV = antiretroviral; FDA = Food and Drug Administration; FDC = fixed-dose combination; FTC = emtricitabine; NRTI = nucleoside reverse transcriptase inhibitor; TAF = tenofovir alafenamide; TDF = tenofovir disoproxil fumarate; ZDV = zidovudine |
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