(Last updated: March 1, 2016; last reviewed: March 1, 2016)
|Adverse Effects||Associated ARVs||Onset/Clinical Manifestations||Estimated Frequencya||Risk Factors||Prevention/ Monitoring||Management|
|ARV Toxic Neuropathyb||
||Limit use of d4T and ddI.
As part of routine care, monitor for symptoms and signs of peripheral neuropathy.
Discontinue offending agent.
Consider referral to a neurologist.
|a Peripheral neuropathy may be underreported in children because symptoms are difficult to evaluate in young children.
b HIV infection itself may cause a distal sensory neuropathy that is phenotypically identical to ARV toxic neuropathy.
Key to Acronyms: ARV = antiretroviral; d4T = stavudine; ddI = didanosine; INH = isoniazid; NRTI = nucleoside reverse transcriptase inhibitor; PI = protease inhibitor