Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

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Management of Medication Toxicity or Intolerance

Peripheral Nervous System Toxicity

Last Updated: April 27, 2017; Last Reviewed: April 27, 2017


  1. Nachman SA, Chernoff M, Gona P, et al. Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era. Arch Pediatr Adolesc Med. 2009;163(2):164-171. Available at
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  4. Banerjee S, McCutchan JA, Ances BM, et al. Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. AIDS. 2011;25(2):F1-6. Available at
  5. Canter JA, Robbins GK, Selph D, et al. African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. J Infect Dis. 2010;201(11):1703-1707. Available at
  6. McCormack PL. Capsaicin dermal patch: in non-diabetic peripheral neuropathic pain. Drugs . 2010;70(14):1831-1842. Available at
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  12. Phan V, Thai S, Choun K, Lynen L, van Griensven J. Incidence of treatment-limiting toxicity with stavudine-based antiretroviral therapy in Cambodia: a retrospective cohort study. PLoS One. 2012;7(1):e30647. Available at
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  14. Peters RP, Van Ramshorst MS, Struthers HE, McIntyre JA. Clinical assessment of peripheral neuropathy in HIV-infected children on antiretroviral therapy in rural South Africa. Eur J Pediatr. 2014;173(9):1245-1248. Available at
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  16. Sankhyan N, Lodha R, Sharma S, et al. Peripheral neuropathy in children on stauvudine therapy. Indian journal of pediatrics. 2015;82(2):136-139. Available at
  17. Chen H, Clifford DB, Deng L, et al. Peripheral neuropathy in ART-experienced patients: prevalence and risk factors. J Neurovirol. 2013;19(6):557-564. Available at
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