Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Management of Medication Toxicity or Intolerance

Peripheral Nervous System Toxicity

Last Updated: May 22, 2018; Last Reviewed: May 22, 2018

References

  1. Nachman SA, Chernoff M, Gona P, et al. Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era. Arch Pediatr Adolesc Med. 2009;163(2):164-171. Available at http://www.ncbi.nlm.nih.gov/pubmed/19188649.
  2. Buck WC, Kabue MM, Kazembe PN, Kline MW. Discontinuation of standard first-line antiretroviral therapy in a cohort of 1,434 Malawian children. J Int AIDS Soc. 2010;13:31. Available at http://www.ncbi.nlm.nih.gov/pubmed/20691049.
  3. Ances BM, Vaida F, Rosario D, et al. Role of metabolic syndrome components in HIV-associated sensory neuropathy. AIDS. 2009;23(17):2317-2322. Available at http://www.ncbi.nlm.nih.gov/pubmed/19823068.
  4. Banerjee S, McCutchan JA, Ances BM, et al. Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. AIDS. 2011;25(2):F1-6. Available at http://www.ncbi.nlm.nih.gov/pubmed/21150557.
  5. Canter JA, Robbins GK, Selph D, et al. African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. J Infect Dis. 2010;201(11):1703-1707. Available at http://www.ncbi.nlm.nih.gov/pubmed/20402593.
  6. Phillips TJ, Cherry CL, Cox S, Marshall SJ, Rice AS. Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials. PLoS One. 2010;5(12):e14433. Available at http://www.ncbi.nlm.nih.gov/pubmed/21203440.
  7. Menezes CN, Maskew M, Sanne I, Crowther NJ, Raal FJ. A longitudinal study of stavudine-associated toxicities in a large cohort of South African HIV infected subjects. BMC Infect Dis. 2011;11:244. Available at http://www.ncbi.nlm.nih.gov/pubmed/21923929.
  8. Wadley AL, Cherry CL, Price P, Kamerman PR. HIV neuropathy risk factors and symptom characterization in stavudine-exposed South Africans. Journal of Pain and Symptom Management. 2011;41(4):700-706. Available at http://www.ncbi.nlm.nih.gov/pubmed/21145196.
  9. Tukei VJ, Asiimwe A, Maganda A, et al. Safety and tolerability of antiretroviral therapy among HIV-infected children and adolescents in Uganda. J Acquir Immune Defic Syndr. 2012;59(3):274-280. Available at http://www.ncbi.nlm.nih.gov/pubmed/22126740.
  10. Webster LR, Peppin JF, Murphy FT, Tobias JK, Vanhove GF. Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain. Journal of Pain Research. 2012;5:7-13. Available at http://www.ncbi.nlm.nih.gov/pubmed/22328830.
  11. Phan V, Thai S, Choun K, Lynen L, van Griensven J. Incidence of treatment-limiting toxicity with stavudine-based antiretroviral therapy in Cambodia: a retrospective cohort study. PLoS One. 2012;7(1):e30647. Available at http://www.ncbi.nlm.nih.gov/pubmed/22303447.
  12. Palmer M, Chersich M, Moultrie H, Kuhn L, Fairlie L, Meyers T. Frequency of stavudine substitution due to toxicity in children receiving antiretroviral treatment in sub-Saharan Africa. AIDS. 2013;27(5):781-785. Available at http://www.ncbi.nlm.nih.gov/pubmed/23169331.
  13. Peters RP, Van Ramshorst MS, Struthers HE, McIntyre JA. Clinical assessment of peripheral neuropathy in HIV-infected children on antiretroviral therapy in rural South Africa. Eur J Pediatr. 2014;173(9):1245-1248. Available at http://www.ncbi.nlm.nih.gov/pubmed/24691679.
  14. Kaku M, Simpson DM. HIV neuropathy. Curr Opin HIV AIDS. 2014;9(6):521-526. Available at http://www.ncbi.nlm.nih.gov/pubmed/25275705.
  15. Sankhyan N, Lodha R, Sharma S, et al. Peripheral neuropathy in children on stauvudine therapy. Indian Journal of Pediatrics. 2015;82(2):136-139. Available at http://www.ncbi.nlm.nih.gov/pubmed/24874810.
  16. Chen H, Clifford DB, Deng L, et al. Peripheral neuropathy in ART-experienced patients: prevalence and risk factors. J Neurovirol. 2013;19(6):557-564. Available at http://www.ncbi.nlm.nih.gov/pubmed/24297499.
  17. Cherry CL, Wadley AL, Kamerman PR. Diagnosing and treating HIV-associated sensory neuropathy: a global perspective. Pain Manag. 2016;6(2):191-199. Available at https://www.ncbi.nlm.nih.gov/pubmed/26988147.
  18. Birbal S, Dheda M, Ojewole E, Oosthuizen F. Adverse drug reactions associated with antiretroviral therapy in South Africa. Afr J AIDS Res. 2016;15(3):243-248. Available at https://www.ncbi.nlm.nih.gov/pubmed/27681148.
  19. Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;1:CD007393. Available at https://www.ncbi.nlm.nih.gov/pubmed/28085183.
  20. Centner CM, Little F, Van Der Watt JJ, et al. Evolution of sensory neuropathy after initiation of antiretroviral therapy. Muscle Nerve. 2017. Available at https://www.ncbi.nlm.nih.gov/pubmed/28561925.
  21. Smyth K, Affandi JS, McArthur JC, et al. Prevalence of and risk factors for HIV-associated neuropathy in Melbourne, Australia 1993-2006. HIV Med. 2007;8(6):367-373. Available at https://www.ncbi.nlm.nih.gov/pubmed/17661844.
  22. Arenas-Pinto A, Thompson J, Musoro G, et al. Peripheral neuropathy in HIV patients in sub-Saharan Africa failing first-line therapy and the response to second-line ART in the EARNEST trial. J Neurovirol. 2016;22(1):104-113. Available at https://www.ncbi.nlm.nih.gov/pubmed/26323809.
  23. Aziz-Donnelly A, Harrison TB. Update of HIV-associated sensory neuropathies. Curr Treat Options Neurol. 2017;19(10):36. Available at https://www.ncbi.nlm.nih.gov/pubmed/28861848.
  24. Ellis RJ, Marquie-Beck J, Delaney P, et al. Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy. Ann Neurol. 2008;64(5):566-572. Available at https://www.ncbi.nlm.nih.gov/pubmed/19067367.

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