Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Management of Children Receiving Antiretroviral Therapy


Last Updated: September 12, 2019; Last Reviewed: September 12, 2019

In the United States, the majority of children living with HIV are receiving antiretroviral therapy (ART), making treatment-experienced children the norm. Providers may consider antiretroviral (ARV) regimen changes for the following reasons:

  • Treatment Simplification: Modifying ARV regimens in children who are currently receiving effective ART in order to simplify the regimen.
  • Treatment Optimization: Increasing the treatment potency or barrier to resistance of an effective, but older or potentially fragile, regimen or improving the adverse event profile.
  • Toxicity Management: Recognizing and managing ARV drug toxicity or intolerance (see Management of Medication Toxicity or Intolerance).
  • Treatment Failure: Recognizing and managing treatment failure (see Recognizing and Managing Antiretroviral Treatment Failure).

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