Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Management of Children Receiving Antiretroviral Therapy

Overview

Last Updated: April 14, 2020; Last Reviewed: April 14, 2020

In the United States, the majority of children living with HIV are receiving antiretroviral therapy (ART), making treatment-experienced children the norm. Providers may consider antiretroviral (ARV) regimen changes for the following reasons:

  • Treatment simplification: Modifying ARV regimens in children who are currently receiving effective ART in order to simplify the regimen.
  • Treatment optimization: Increasing the treatment potency or barrier to resistance of an effective, but older or potentially fragile, regimen or improving the adverse event profile.
  • Toxicity management: Recognizing and managing ARV drug toxicity or intolerance (see Management of Medication Toxicity or Intolerance).
  • Treatment failure: Recognizing and managing treatment failure (see Recognizing and Managing Antiretroviral Treatment Failure).

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