Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Management of Children Receiving Antiretroviral Therapy


Last Updated: May 22, 2018; Last Reviewed: May 22, 2018

In the United States, the majority of children living with HIV are receiving antiretroviral therapy (ART), making treatment-experienced children the norm. Changes to the antiretroviral (ARV) regimen and other aspects of the management of treatment-experienced children can be organized into the following categories:

  1. Modifying ARV regimens in children who are currently receiving effective ART in order to simplify the regimen or to improve the adverse event profile
  2. Recognizing and managing ARV drug toxicity or intolerance (see Management of Medication Toxicity or Intolerance)
  3. Recognizing and managing treatment failure
  4. Increasing the treatment potency or barrier to resistance of an effective, but older or potentially fragile, regimen

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