Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

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Appendix B: Acronyms

General Terms

Last Updated: May 22, 2018; Last Reviewed: May 22, 2018

General Terms
Acronym Term
°C degrees Celsius
°F degrees Fahrenheit
AE adverse effect
ALP alkaline phosphatase
ALT alanine aminotransferase
ANC absolute neutrophil count
APHL Association of Public Health Laboratories
ART antiretroviral therapy
ARV antiretroviral
AST aspartate aminotransferase
AUC area under the curve
AUC0-12h area under the curve at 12 hours post-dose
AUC24h area under the curve at 24 hours post-dose
AV atrioventricular
BCRP breast cancer resistance protein
BID twice daily
BMD bone mineral density
BMI body mass index
BSA body surface area
C0h pre-dose concentration
C12 or C12h mid-dose concentration
CBC complete blood count
CD4 CD4 T lymphocyte
CDC Centers for Disease Control and Prevention
CI confidence interval
CK creatine kinase
Cmax maximum plasma concentration
Cmin minimum plasma concentration
CMV cytomegalovirus
CNS central nervous system
CrCl creatinine clearance
CT continuous therapy
CV coefficients of variation
CVD cardiovascular disease
CYP cytochrome P
dL deciliter
DM diabetes mellitus
DMPA depot medroxyprogesterone acetate
DNA deoxyribonucleic acid
DOT directly observed therapy
DRESS drug reaction (or rash) with eosinophilia and systemic symptoms
DSMB Data Safety Monitoring Board
DXA dual energy x-ray absorptiometry
EBV Epstein-Barr virus
EC enteric-coated
ECG or EKG electrocardiogram
EEG electroencephalogram
eGFR estimated glomerular filtration rate
EM erythema multiforme or extensive metabolizers
EMA European Medicines Agency
FDA Food and Drug Administration
FDC fixed-dose combination
fL femtoliter
fmol femtomole
FLP fasting lipid profile
FPG fasting plasma glucose
G6PD glucose-6-phosphate dehydrogenase
GFR glomerular filtration rate
GI gastrointestinal
GM geometric mean
HAV hepatitis A virus
HBV hepatitis B virus
HCV hepatitis C virus
HDL-C high-density lipoprotein cholesterol
Hgb hemoglobin
HgbA1c glycosylated hemoglobin
HHS Department of Health and Human Services
HIV RNA or HIV-1 RNA viral load
HLA human leukocyte antigen
HPV human papilloma virus
HRSA Health Resources and Services Administration
HSR hypersensitivity reaction
HSV herpes simplex virus
IAS-USA International Antiviral Society-USA
ICH intracranial hemorrhage
INH isoniazid
INSTI integrase strand transfer inhibitor
IQ inhibitory quotient
IQR interquartile range
IRIS immune reconstitution inflammatory syndrome
IU international units
IV intravenous
IVIG intravenous immune globulin
kg kilogram
L liter
LDL low-density lipoprotein
LDL-C low-density lipoprotein cholesterol
LFT liver function test
LLD lower level of detection
LLQ lower limits of quantitation
LS lipodystrophy syndrome
mcg or μg microgram
MCV mean cell volume
mg milligram
min minute
mL milliliter
mm millimeter
NASBA nucleic acid sequence-based amplification
NAT nucleic acid test
ng nanogram
NHLBI National Heart, Lung, and Blood Institute
NIH National Institutes of Health
NNRTI non-nucleoside reverse transcriptase inhibitor
NRTI nucleoside reverse transcriptase inhibitor
OARAC Office of AIDS Research Advisory Council
OBT optimized background therapy
OGTT oral glucose tolerance test
OI opportunistic infection
oz ounce
PBMC peripheral blood mononuclear cell
PCP Pneumocystis jirovecii pneumonia
PCR polymerase chain reaction
PEP post-exposure prophylaxis
PG plasma glucose
P-gp P-glycoprotein
PI protease inhibitor
PK pharmacokinetic
PPI proton pump inhibitor
PUFA polyunsaturated fatty acid
py patient years
QTc corrected QT
RBV ribavirin
RNA ribonucleic acid
RPG random plasma glucose
RT-PCR reverse transcription polymerase chain reaction
SCT short-cycle therapy
SD standard deviation
SDD study drug discontinuation
SJS Stevens-Johnson syndrome
SM slow metabolizers
SMR sexual maturity rating
SQ subcutaneous
STI sexually transmitted infection
T½ half-life
TB tuberculosis
TC total cholesterol
TDM therapeutic drug monitoring
TEN toxic epidermal necrolysis
TFV tenofovir
TFV-DP tenofovir diphosphate
TG triglyceride
THAM tris (hydroxymethyl) aminomethane
Tmax time to reach maximum concentration
TMP-SMX trimethoprim sulfamethoxazole
UGT uridine diphosphate glucuronosyltransferase
ULN upper limit of normal
VLS viral load suppression
WHO World Health Organization

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