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Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States

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Non-Nucleoside Reverse Transcriptase Inhibitors

Overview

Glossary of Terms for Supplement
Glossary of Terms for Supplement
Carcinogenic = producing or tending to produce cancer
  • Some agents, such as certain chemicals or forms of radiation, are both mutagenic and clastogenic.
  • Genetic mutations and/or chromosomal damage can contribute to cancer formation.
Clastogenic = causing disruption of or breakages in chromosomes
Genotoxic = damaging to genetic material such as DNA and chromosomes
Mutagenic = inducing or capable of inducing genetic mutation
Teratogenic = interfering with fetal development and resulting in birth defects

Five non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) are currently approved: delavirdine, efavirenz, etravirine, nevirapine and rilpivirine. Delavirdine is no longer available in the United States.

For information about potential interactions between NNRTIs and methergine, see the Postpartum Hemorrhage, Antiretroviral Drugs, and Methergine Use sections.

Efavirenz (Sustiva, EFV)
Etravirine (Intelence, ETR)
Nevirapine (Viramune, NVP)
Rilpivirine (Edurant. RPV)

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