Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States

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Non-Nucleoside Reverse Transcriptase Inhibitors


Glossary of Terms for Supplement
Glossary of Terms for Supplement
Carcinogenic = producing or tending to produce cancer
  • Some agents, such as certain chemicals or forms of radiation, are both mutagenic and clastogenic.
  • Genetic mutations and/or chromosomal damage can contribute to cancer formation.
Clastogenic = causing disruption of or breakages in chromosomes
Genotoxic = damaging to genetic material such as DNA and chromosomes
Mutagenic = inducing or capable of inducing genetic mutation
Teratogenic = interfering with fetal development and resulting in birth defects

Five non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) are currently U.S. Food and Drug Administration (FDA) approved: delavirdine, efavirenz, etravirine, nevirapine, and rilpivirine. Delavirdine is no longer available in the United States.

Efavirenz (Sustiva, EFV)
Etravirine (Intelence, ETR)
Nevirapine (Viramune, NVP)
Rilpivirine (Edurant. RPV)

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