Overview Perinatal

Non-Nucleoside Reverse Transcriptase Inhibitors

Glossary of Terms for Supplement
Glossary of Terms for Supplement
Carcinogenic = producing or tending to produce cancer Some agents, such as certain chemicals or forms of radiation, are both mutagenic and clastogenic. Genetic mutations and/or chromosomal damage can contribute to cancer formation. Clastogenic = causing disruption of or breakages in chromosomes Genotoxic = damaging to genetic material such as DNA and chromosomes Mutagenic = inducing or capable of inducing genetic mutation Teratogenic = interfering with fetal development and resulting in birth defects

Five non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) are currently approved: delavirdine, efavirenz, etravirine, nevirapine and rilpivirine. Delavirdine is no longer available in the United States.

For information about potential interactions between NNRTIs and methergine, see the Postpartum Hemorrhage, Antiretroviral Drugs, and Methergine Use sections.

Efavirenz (Sustiva, EFV)
Etravirine (Intelence, ETR)
Nevirapine (Viramune, NVP)
Rilpivirine (Edurant. RPV)