Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

What's New in the Guidelines

Updates to the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV Infected Adults and Adolescents document was published in an electronic format that could be easily updated as relevant changes in prevention and treatment recommendations occur.

The editors and subject matter experts are committed to timely changes in this document because so many health care providers, patients, and policy experts rely on this source for vital clinical information.

All changes are developed by the subject matter groups listed in the document (changes in group composition are also promptly posted). These changes are reviewed by the editors and by relevant outside reviewers before the document is altered. Major revisions within the last 6 months are as follows:

May 29, 2018

  1. Human Papillomavirus Disease: The panel added a recommendation for ASC-US with negative reflex HPV: For ASC-US Pap test, if reflex HPV testing is negative, a repeat Pap test in 6-12 months or repeat co-testing in 12 months is recommended. For any result ≥ ASC-US on repeat cytology, referral to colposcopy is recommended (AII).
  2. Introduction: The section was updated to reflect current information about the panel’s processes, policies, and membership.

March 7, 2018

  1. Human Papillomavirus Disease: The section has been updated to recommend the 9-valent HPV vaccine for women and men, and continued Pap and HPV testing for women who are over 65 and living with HIV. The revised text includes more information on oropharyngeal warts and cancer related to HPV.

February 21, 2018

  1. Human Herpesvirus-8: The epidemiology of HHV-8 infection and HHV-8 related malignancies has been revised to reflect current data, and information about the newly described clinical syndrome, the KSHV inflammatory cytokine syndrome (KICS), is provided. Treatment recommendations for multicentric Castleman's disease have been updated.

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