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Clinical Guidelines Portal

Clinical Guidelines Portal

Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

What's New in the Guidelines

(Last updated: May 3, 2016; last reviewed: May 3, 2016)

Updates to the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

The Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV Infected Adults and Adolescents document was published in an electronic format that could be easily updated as relevant changes in prevention and treatment recommendations occur.

The editors and subject matter experts are committed to timely changes in this document because so many health care providers, patients, and policy experts rely on this source for vital clinical information.

All changes are developed by the subject matter groups listed in the document (changes in group composition are also promptly posted). These changes are reviewed by the editors and by relevant outside reviewers before the document is altered.

Major revisions within the last 6 months are as follows:

May 3, 2016

  1. Bacterial Enteric Infections: This section has been updated to include new information on the growing issue of antibiotic resistance among enteric bacteria as well as updated information on treatment of enteric infections, including in pregnant women.

December 17, 2015

  1. Syphilis: This section has been updated. New information is summarized about current testing algorithms for syphilis. Discussion of management of patients with sexual risk history is expanded in terms of diagnostic and therapeutic approaches. Recommendations for the diagnosis and management of neurosyphilis and ocular syphilis have been more extensively delineated. Updated recommendations for treatment and retreatment options for syphilis in non-pregnant and pregnant persons are also provided.

December 8, 2015

  1. CandidaThe section has been updated to provide clinicians with guidance on the use of topical and systemic antifungal agents to treat oropharyngeal candidiasis.

November 4, 2015

  1. Cytomegalovirus: This revision provides guidance for the management of Cytomegalovirus (CMV) retinitis which develops or worsens in the setting of ART initiation. Data supporting the treatment of CMV retinitis with systemic anti-CMV therapy for prevention of contralateral eye and visceral disease are discussed. The term “Secondary Prophylaxis” is replaced by “Maintenance Therapy”.

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