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Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children

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Appendices

Appendix 1. Important Guideline Considerations

Last Updated: December 15, 2016; Last Reviewed: December 15, 2016

NIH-CDC-HIVMA/IDSA-PIDS-AAP Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children
Topic Comment
Goal of the Guidelines Provide guidance to HIV care practitioners on the prevention and management of HIV-related opportunistic infections for HIV-exposed and HIV-infected children in the United States.
Panel Members
The panel is composed of the Executive Secretary and two non-governmental Co-Chairs with expertise in pediatric HIV infection and infectious diseases. The panel has members who represent the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), the HIV Medical Association of the Infectious Disease Society of America (HIVMA/IDSA), the Pediatric Infectious Disease Society (PIDS), the American Academy of Pediatrics (AAP), plus approximately 30 members with expertise in HIV clinical care, infectious disease management, and research in children. The panel members are selected from government, academia, and the healthcare community by the Executive Secretary and Co-Chairs and assigned to a working group for one or more of the guidelines’ sections based on the member’s area of subject matter expertise. Each working group is chaired by a panel member selected by the co-chairs. Members serve on the panel for a four-year term, with an option to be reappointed for additional terms. The list of the current working group members can be found in Appendix 2.
Financial Disclosure and Management of Conflicts of Interest 
All members of the panel submit an annual written financial disclosure reporting any associations with manufacturers of drugs, vaccines, medical devices, or diagnostics used to manage HIV-related opportunistic infections. A list of these disclosures and the date of their last update are available in Appendix 3. The panel co-editors review each reported association for potential conflict of interest and determine the appropriate action: disqualification from the panel, disqualification/recusal from topic review and discussion, or no disqualification needed. A conflict of interest is defined as any direct financial interest related to a product addressed in the section of the guidelines to which a panel member contributes content. Financial interests include direct receipt by the panel member of payments, gratuities, consultancies, honoraria, employment, grants, support for travel or accommodation, or gifts from an entity having a commercial interest in that product. Financial interest also includes direct compensation for membership on an advisory board, data safety monitoring board, or speakers’ bureau. Compensation and support that filters through a working group member’s university or institution (e.g., grants, research funding) is not considered a conflict of interest. 
Users of the Guidelines
Pediatric HIV treatment providers in the United States
Developer
Panel on Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children—a working group of the Office of AIDS Research (OAR) Advisory Council
Funding Source
OAR, NIH
Other Guidelines These guidelines focus on prevention and treatment of HIV-related opportunistic infections for HIV-exposed and HIV-infected children in the United States. A separate set of guidelines outlines similar recommendations for adults. These guidelines are also available on the AIDSinfo website (http://www.aidsinfo.nih.gov).
Update Plan
Each working group and the co-editors meet at least every 6 months by teleconference to review data that may warrant modification of the guidelines. Updates may be prompted by approvals of new drugs, vaccines, medical devices, or diagnostics; by new information regarding indications or dosing; by new safety or efficacy data; or by other information that may affect prevention and treatment of HIV-related opportunistic infections. Updates that may significantly affect patient safety or treatment and that warrant rapid notification may be posted temporarily on the AIDSinfo website (http://www.aidsinfo.nih.gov) until the guidelines document can be updated.
Public Comments
After release of an update on the AIDSinfo website, the public is given a 2-week period to submit comments to the panel. These comments are reviewed, and a determination is made by the appropriate working group and the co-editors as to whether revisions are indicated. The public may also submit comments to the Panel at any time at contactus@aidsinfo.nih.gov

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