Guidance for Non-HIV-Specialized Providers Caring for Persons with HIV Who Have been Displaced by Disasters (such as a Hurricane)

The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations.

Appendix C: Antiretroviral Medications that Can Be Switched Temporarily Due to Supply Shortage

Last Updated: September 14, 2018; Last Reviewed: September 14, 2018

Clinicians are encouraged to consult an HIV specialist with additional questions about regimen switches, if needed. Many drugs that are used to treat HIV have significant interactions with other drugs that are used to treat HIV or other conditions. Before making changes to an HIV drug regimen or prescribing any new medicine to a person on antiretroviral therapy, evaluate the new medication for drug-drug interactions with concomitant medications. Tenofovir disoproxil fumarate (tenofovir DF)-based products may require dosage adjustment in patients with renal dysfunction. Dose recommendations can be found at: go.usa.gov/xPgTf.

Appendix C: Antiretroviral Medications that Can Be Switched Temporarily Due to Supply Shortage
Brand (Generic Names) Replace with – Brand (Generic Names)
Atripla (efavirenz + tenofovir DF + emtricitabine) Sustiva (efavirenz) + Truvada (tenofovir DF + emtricitabine) or

Sustiva (efavirenz) + Descovy (tenofovir alafenamide + emtricitabine) or

Symfi (efavirenz + tenofovir DF + lamivudine)
Biktarvy (bictegravir + tenofovir alafenamide + emtricitibine) Tivicay (dolutegravir) + Descovy (tenofovir alafenamide + emtricitabine) or

Tivicay (dolutegravir) + Truvada (tenofovir DF + emtricitabine)
Cimduo (tenofovir DF + lamivudine) Truvada (tenofovir DF + emtricitabine) or

Descovy (tenofovir alafenamide + emtricitabine)
Combivir (zidovudine + lamivudine) Retrovir (zidovudine) + Epivir (lamivudine) or

Generic zidovudine + generic lamivudine
Complera (rilpivirine + tenofovir DF + emtricitabine) Edurant (rilpivirine) + Truvada (tenofovir DF + emtricitabine) or

Edurant (rilpivirine) + Descovy (tenofovir alafenamide + emtricitabine) or

Odefsey (rilpivirine + tenofovir alafenamide + emtricitabine)
Descovy (tenofovir alafenamide + emtricitabine) Vemlidy (tenofovir alafenamide) + Emtriva (emtricitabine) or

Truvada (tenofovir DF + emtricitabine) or

Cimduo (tenofovir DF + lamivudine) or

Viread (tenofovir DF) + Emtriva (emtricitabine) or

Viread (tenofovir DF) + Epivir (lamivudine) 300 mg

Note: Lamivudine is also available as a generic drug.
Emtriva (emtricitabine) Epivir (lamivudine)

Note: Lamivudine is also available as a generic drug.
Epivir (lamivudine) Generic lamivudine or

Emtriva (emtricitabine)
Epzicom (abacavir + lamivudine) Ziagen (abacavir) + Epivir (lamivudine)
Evotaz (atazanavir + cobicistat) Reyataz (atazanavir) + Tybost (cobicistat) or

Reyataz (atazanavir) + Norvir (ritonavir) 100 mg
Genvoya (elvitegravir + cobicistat + tenofovir alafenamide + emtricitabine) Stribild (elvitegravir + cobicistat + tenofovir DF + emtricitabine), only if creatinine clearance (CrCl) >70 mL/min. Consult an HIV expert if CrCl <70 mL/min, or

Biktarvy (bictegravir + tenofovir alafenamide + emtricitibine) or

Tivicay (dolutegravir) + Descovy (tenofovir alafenamide + emtricitabine)
Isentress HD (raltegravir once-daily formulation—two 600-mg tablets per day) Isentress (raltegravir) 400 mg twice daily
Juluca (dolutegravir + rilpivirine) Tivicay (dolutegravir) + Edurant (rilpivirine)
Odefsey (rilpivirine + tenofovir alafenamide + emtricitabine) Edurant (rilpivirine) + Descovy (tenofovir alafenamide + emtricitabine) or

Edurant (rilpivirine) + Truvada (tenofovir DF + emtricitabine) or

Complera (rilpivirine + tenofovir DF + emtricitabine)
Prezcobix (darunavir + cobicistat) Prezista (darunavir) + Tybost (cobicistat) or

Prezista (darunavir) + Norvir (ritonavir) 100 mg
Stribild (elvitegravir + cobicistat + tenofovir DF + emtricitabine) Genvoya (elvitegravir + cobicistat + tenofovir alafenamide + emtricitabine) or

Biktarvy (bictegravir + tenofovir alafenamide + emtricitibine) or

Tivicay (dolutegravir) + Descovy (tenofovir alafenamide + emtricitabine)
Symfi (efavirenz + tenofovir DF + lamivudine) Atripla (efavirenz + tenofovir DF + emtricitabine) or

Sustiva (efavirenz) + Truvada (tenofovir DF + emtricitabine) or

Sustiva (efavirenz) + Descovy (tenofovir alafenamide + emtricitabine)
Triumeq (dolutegravir + abacavir + lamivudine) Tivicay (dolutegravir) + Epzicom (abacavir + lamivudine) or

Tivicay (dolutegravir) + Ziagen (abacavir) + Epivir (lamivudine)

Note: Abacavir and lamivudine are also available as generic products.
Trizivir (abacavir + zidovudine + lamivudine)

Please note that the replacement products may have different doses or dose frequencies—consult product labels for dose information.
Ziagen (abacavir) + Retrovir (zidovudine) + Epivir (lamivudine) or

Epzicom (abacavir + lamivudine) + Retrovir (zidovudine) or

Combivir (zidovudine + lamivudine) + Ziagen (abacavir) or

Generic formulations of these products (as individual drugs or in combination)

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