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Guidance for Non-HIV-Specialized Providers Caring for Persons with HIV Displaced by Disasters

Appendix C: Antiretroviral Medications that Can Be Switched Temporarily Due to Supply Shortage

Last Updated: August 31, 2017; Last Reviewed: August 31, 2017

Clinicians are encouraged to consult an HIV specialist with additional questions about regimen switches, if needed. Tenofovir disoproxil fumarate (tenofovir DF)-based products may require dosage adjustment in patients with renal dysfunction. Dosage recommendations can be found at: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/44/arv-dosing-for-renal-or-hepatic-insufficiency.

Appendix C: Antiretroviral Medications that Can Be Switched Temporarily Due to Supply Shortage
Brand (Generic Names) Replace with – Brand (Generic Names)
Atripla (efavirenz + tenofovir DF + emtricitabine) Sustiva (efavirenz) + Truvada (tenofovir DF + emtricitabine) or

Sustiva (efavirenz) + Descovy (tenofovir alafenamide + emtricitabine)
Combivir (zidovudine + lamivudine) Retrovir (zidovudine) + Epivir (lamivudine) or

Generic zidovudine + generic lamivudine
Complera (rilpivirine + tenofovir DF + emtricitabine) Edurant (rilpivirine) + Truvada (tenofovir DF + emtricitabine) or

Edurant (rilpivirine) + Descovy (tenofovir alafenamide + emtricitabine) or

Odefsey (rilpivirine + tenofovir alafenamide + emtricitabine)
Descovy (tenofovir alafenamide + emtricitabine) Vemlidy (tenofovir alafenamide) + Emtriva (emtricitabine) or

Truvada (tenofovir DF + emtricitabine) or

Viread (tenofovir DF) + Emtriva (emtricitabine) or

Viread (tenofovir DF) + Epivir (lamivudine) 300 mg
Note: Lamivudine is also available as generic drug.
Emtriva (emtricitabine) Epivir (lamivudine)
Note: Lamivudine is also available as generic drug.
Epivir (lamivudine) Generic lamivudine

Emtriva (emtricitabine)
Epzicom (abacavir + lamivudine) Ziagen (abacavir) + Epivir (lamivudine)
Evotaz (atazanavir + cobicistat) Reyataz (atazanavir) + Tybost (cobicistat) or

Reyataz (atazanavir) + Norvir (ritonavir) 100 mg
Genvoya (elvitegravir + cobicistat + tenofovir alafenamide + emtricitabine) Stribild (elvitegravir + cobicistat + tenofovir DF + emtricitabine)—only if creatinine clearance (CrCl) >70 mL/min. Consult an HIV expert if CrCl <70 mL/min.
Odefsey (rilpivirine + tenofovir alafenamide + emtricitabine) Edurant (rilpivirine) + Descovy (tenofovir alafenamide + emtricitabine) or

Edurant (rilpivirine) + Truvada (tenofovir DF + emtricitabine) or

Complera (rilpivirine + tenofovir DF + emtricitabine)
Prezcobix (darunavir + cobicistat) Prezista (darunavir) + Tybost (cobicistat) or

Prezista (darunavir) + Norvir (ritonavir) 100 mg
Stribild (elvitegravir + cobicistat + tenofovir DF + emtricitabine) Genvoya (elvitegravir + cobicistat + tenofovir alafenamide + emtricitabine)
Triumeq (dolutegravir + abacavir + lamivudine) Tivicay (dolutegravir) + Epzicom (abacavir + lamivudine) or

Tivicay (dolutegravir) + Ziagen (abacavir) + Epivir (lamivudine)
Note: Abacavir and lamivudine are also available as generic products.
Trizivir (abacavir + zidovudine + lamivudine)

Please note that the replacement products may have different dosage or dosage frequency—consult product labels for dosage information.
Ziagen (abacavir) + Retrovir (zidovudine) + Epivir (lamivudine) or

Epzicom (abacavir + lamivudine) + Retrovir (zidovudine) or

Combivir (zidovudine + lamivudine) + Ziagen (abacavir) or

Generic formulations of these products (as individual drugs or in combination)

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