What's What in NIAID-Supported HIV Vaccine Research

Date: January 1, 1995
Source: National Institutes of Health (NIH)
Author: National Institute of Allergy and Infectious Diseases (NIAID)

AIDS Cooperative Adjuvant Groups conduct preclinical studies of adjuvants and vaccine-adjuvant combinations.

AIDS Vaccine Reagent Project provides large quantities of reagents for preclinical and clinical studies related to vaccines.

Antibody Serologic Project identifies and standardizes monoclonal antibodies to characterize specific components of HIV and SIV.

AVEG (AIDS Vaccine Evaluation Group) includes six centers conducting Phase I and II trials of potential HIV vaccines.

AVEU (AIDS Vaccine Evaluation Unit) is an individual clinical site in the AVEG.

Chimpanzee Unit is a site for the evaluation of HIV vaccine concepts and products in chimpanzees.

Cooperative Mucosal Immunology Group for Investigations on AIDS Vaccines examines ways to stimulate and evaluate mucosal immune responses to HIV and SIV infection and vaccines.

DSMB (Data and Safety Monitoring Board) is an independent committee associated with the AVEG that reviews data of trials in progress to ensure that no participant is exposed to undue risk.

HIV Sequence Database and Analysis Unit is a part of HIV Variation Project.

HIV Variation Project addresses vaccine development problems related to HIV's genetic diversity.

HIVNET (HIV Vaccine Efficacy Trials Network) is a set of contracts that provide an infrastructure for the preparation for and eventual conduct of large-scale efficacy trials of HIV vaccines and prevention strategies.

Immunology Laboratory Support for Assessment of AIDS Vaccines in Pri-mates standardizes immunology tests to assess responses to SIV and HIV vaccines.

NCVDG (National Cooperative Vaccine Development Groups) are teams of scientists from government, academia and industry developing and testing novel experimental HIV vaccine concepts in laboratory and animal studies.

PAVE (Preparation for AIDS/HIV Vaccine Evaluations) is a program to determine the feasibility of conducting vaccine efficacy trials abroad.

Primate Research Laboratories study chimpanzees and monkeys to answer AIDS vaccine-related questions.

SIV VEU (SIV Vaccine Evaluation Unit) evaluates SIV vaccine candidates in monkeys.

NIAID, a component of the National Institutes of Health, supports research on AIDS, tuberculosis and other infectious diseases as well as allergies and immunology. NIH is an agency of the U.S. Public Health Service, U.S. Department of Health and Human Services.

Prepared by:
Office of Communications National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD 20892
Public Health Service U.S. Department of Health and Human Services