NIH Seeks Input on HIV Cure Research Priorities

Date: March 3, 2014
Source: National Institutes of Health (NIH)
Author: National Institute of Allergy and Infectious Diseases (NIAID)

Responses Will Help Inform Allocation of $100 Million Research Investment

The National Institutes of Health (NIH) is asking the scientific community to weigh in on what should be the highest priority research areas related to understanding HIV persistence and investigating strategies for eradicating or controlling remaining virus despite optimal antiretroviral treatment. Responses to the new request for information (RFI), “Areas of Research Aimed at a Cure or Lifelong Remission of HIV Infection,” are intended to help guide the NIH HIV Cure Initiative—a $100 million allocation of funds announced in December 2013 aimed at research to find a cure or establish lifelong remission from HIV infection in the absence of antiretroviral therapy.
NIH currently supports a broad program of HIV cure-related research including basic science, adult and pediatric clinical research and studies on neurological conditions occurring as a result of HIV infection. The funds made available through the new NIH HIV Cure Initiative will allow for additional support for the highest priority research topics. Input from the scientific community will help NIH identify those most important HIV cure research areas.
The RFI invites the scientific community to provide comments that can include but are not limited to

  • High-priority HIV cure-related research topics and the information, technologies and resources needed to facilitate them
  • The optimal combination of basic, translational and clinical evaluations that would best advance cure research
  • The most appropriate grant mechanisms for funding cure research
  • Existing cure-related initiatives that should be either expanded or abolished
  • Areas of HIV cure-related research that should be considered low-priority, and approaches that have already been or are currently being sufficiently explored

The NIH components that issued the RFI include: the National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute (NCI), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), the National Institute of Neurological Disorders and Stroke (NINDS) and the NIH Office of AIDS Research (OAR).
NIH will accept responses through March 14, 2014. Respondents should reply by email to and include “RFI Reply” in the subject line.  For more information, see Request for Information (RFI): Areas of Research Aimed at a Cure or Lifelong Remission of HIV Infection.