Could transfusions of white blood cells from healthy relatives help restore CD4+ T cell levels in individuals with advanced HIV infection? To find out, NIAID-supported investigators recently opened a phase I clinical study of this strategy, known as allogeneic lymphocyte transfer.
The trial is based on studies that have shown dramatic increases in CD4+ and CD8+ T cell counts in some HIV-infected individuals transfused with white blood cells from a noninfected sibling. The current study will assess the safety of this procedure when other relatives, in addition to siblings, are used as donors, and will quantify the extent to which it can replenish immune cells in patients with HIV.
Investigators seek HIV-infected volunteers for the study. Eligible participants must have CD4+ T cell counts between 50 and 200 cells per cubic millimeter (mm3) of blood, no ongoing major opportunistic infections, and have been on stable antiretroviral therapy for the past two months, in addition to meeting other eligibility criteria.
Each volunteer will receive three separate infusions of white blood cells donated by a healthy sibling, parent, or adult child with matching blood type. Infusions will be administered at four-week intervals. Volunteers will undergo weekly evaluations during a four-month followup period. After that, researchers will contact study participants by telephone periodically over the next three years.
Known as Division of AIDS Treatment Research Initiative (DATRI) 016, the study is being conducted by researchers at University Hospital of Cleveland, Ohio. Individuals interested in participating in the study should call Michael Chance, at 216-844-8051 or 8175 for more information. For information about other AIDS-related clinical trials, call the AIDS Clinical Trials Information Service, at 1-800-TRIALS-A (TDD 1-800-448-0440).