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Future NIAID AIDS Treatment Strategies Will Be Based on Greater Understanding of HIV Disease Mechanisms

Date: November 11, 1993
Source: National Institutes of Health (NIH)
Author: National Institute of Allergy and Infectious Diseases (NIAID)

The complexity of the HIV disease process will serve as a paradigm for the future design of comprehensive AIDS treatment strategies, says Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID) and chief of the NIAID Laboratory of Immunoregulation. Writing in the Nov. 12 Science, Dr. Fauci outlines a framework for fighting HIV disease, citing the need to:

  • develop antiviral therapies effective throughout the course of HIV infection,
  • block the inappropriate activation of an HIV-infected person's immune system without worsening immune deficiency,
  • selectively inhibit the inappropriate secretion of proteins called cytokines by an HIV-infected patient's immune cells or block the action of these proteins and
  • reconstitute the damaged immune system of an HIV-infected person.

Copies of Dr. Fauci's article, "Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy," can be obtained by calling Science at (202) 326- 6440.