HIV/AIDS Glossary

Surrogate Endpoint

Synonym(s): Surrogate Marker

Substitute measure for a clinical endpoint. Because it can be difficult to measure clinical endpoints in studies running for several years, researchers often use surrogate endpoints as substitute measures for clinical endpoints. For example, in HIV-related clinical trials, HIV viral load (VL) and CD4 T lymphocyte (CD4) count are surrogate endpoints for HIV disease progression.

Related Term(s): Clinical Endpoint, Clinical Trial

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