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HIV/AIDS Glossary

Integrase

An enzyme found in HIV (and other retroviruses). HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host CD4 cell. Integration is a crucial step in the HIV life cycle and is targeted by a class of antiretroviral (ARV) HIV drugs called integrase strand transfer inhibitors (INSTIs).

Related Term(s): Integrase Strand Transfer Inhibitor, Integration, Life Cycle, Provirus

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Integration is step four of HIV replication.

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