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HIV/AIDS Glossary

Integrase Strand Transfer Inhibitor (INSTI)

Synonym(s): Integrase Inhibitor

Antiretroviral (ARV) HIV drug class. Integrase strand transfer inhibitors (INSTIs) block integrase (an HIV enzyme). HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host CD4 cell. Blocking integrase prevents HIV from replicating.

Related Term(s): Drug Class, Integrase

Image(s):

(Click to enlarge)
Integrase strand transfer inhibitor blocks HIV replication.
Integration is step four of HIV replication.

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