HIV/AIDS Glossary

Dual/Mixed Tropic Virus

Synonym(s): D/M-Tropic Virus

A strain of HIV that includes a combination of R5-tropic virus and X4-tropic virus (mixed-tropic virus) and/or a virus that uses either the CCR5 or the CXCR4 coreceptor (dual-tropic virus). To enter a host CD4 T lymphocyte (CD4 cell), HIV must first attach to a CD4 receptor, then attach to either a CCR5 or CXCR4 coreceptor, and finally fuse its membrane with the CD4 cell membrane.

Related Term(s): CCR5, CXCR4, Dual-Tropic Virus, Mixed-Tropic HIV, R5-Tropic Virus, X4-Tropic Virus

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