HIV/AIDS Glossary

CXCR4 Antagonist

CXCR4 antagonists are a class of drugs that block the CXCR4 coreceptor on the surface of certain immune cells, such as CD4 T lymphocytes (CD4 cells). This prevents HIV from entering the cell. CXCR4 antagonists are part of a larger class of HIV drugs called entry inhibitors. Currently, CXCR4 antagonists are still under investigation and have not been approved by the Food and Drug Administration (FDA) for patient use.

Related Term(s): CXCR4, Entry Inhibitor, Investigational Drug

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