HIV/AIDS Glossary

Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Synonym(s): Non-Nucleoside Analogue Reverse Transcriptase Inhibitor

Antiretroviral (ARV) HIV drug class. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

Related Term(s): Drug Class, Reverse Transcriptase, Reverse Transcription


(Click to enlarge)
NNRTIs and NRTIs  block reverse transcription.
Reverse transcription is the third step of HIV replication.

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