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HIV/AIDS Glossary

Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Synonym(s): Nucleoside Analogue Reverse Transcriptase Inhibitor

Antiretroviral (ARV) HIV drug class. Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

Related Term(s): Drug Class, Nucleotide Reverse Transcriptase Inhibitor, Reverse Transcriptase, Reverse Transcription

Image(s):

(Click to enlarge)
NNRTIs and NRTIs  block reverse transcription.
Reverse transcription is the third step of HIV replication.

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